May function as a negative regulator of inflammatory responses and innate immunity. May reduce cytokine release in response to bacterial lipopolysaccharide during infection. Reduces activation of NF-kappa-B in response to TNF (PubMed:15129283). May lack protease activity (Probable). {ECO:0000269|PubMed:15129283, ECO:0000305|PubMed:12054529}. This is the function of Ensembl gene identifier ENSG00000204403 (CASP12, caspase 12 (gene/pseudogene)).