The function of FBXO16 (F-box protein 16, Ensembl gene identifier ENSG00000214050) is as follows. Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Functions as a putative tumor suppressor by targeting nuclear beta-catenin/CTNNB1 for degradation independently of upstream activating signals, thereby inhibiting epithelial-to-mesenchymal transition (PubMed:30714168). Controls the ubiquitination and degradation of hnRNPL (PubMed:34333526). Negatively regulates NF-kappa- B signaling by mediating the polyubiquitination and degradation of RELA (PubMed:40529355). Inhibits autophagy by promoting 'Lys-48'-linked polyubiquitination of the serine/threonine-protein kinase ULK1 (PubMed:39384743). {ECO:0000269|PubMed:30714168, ECO:0000269|PubMed:34333526, ECO:0000269|PubMed:39384743, ECO:0000269|PubMed:40529355}.