Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide (By similarity). Also binds odorants cis-cyclooctene and tert-butyl mercaptan (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). . This is the function of Ensembl gene identifier ENSG00000221977 (OR4E2, olfactory receptor family 4 subfamily E member 2).