Catalyzes the hydrolysis of inositol from phosphatidylinositol (1,2-diacyl-sn-glycero-3-phospho-(1D-myo- inositol), PI) (PubMed:22732399). Could also hydrolyze various multi- phosphorylated derivatives of PI, such as phosphatidylinositol-4,5 bisphosphate (PIP2), releasing inositol-1,4,5-trisphosphate (IP3) and the protein kinase C activator diacylglycerol (DAG), therefore mediating cell signaling (Probable). {ECO:0000269|PubMed:22732399, ECO:0000305|PubMed:22732399}. This is the function of PLCXD2 (phosphatidylinositol specific phospholipase C X domain containing 2, Ensembl gene identifier ENSG00000240891).