Precursor of neuropeptides that bind to all somatostatin receptor (SSTR) subtypes (PubMed:9125122). Inhibits cAMP production induced by forskolin through SSTRs (PubMed:9125122). . [Cortistatin-14]: Neuropeptide with neuronal depressant and sleep-modulating properties (By similarity). Acts as a ligand for MRGPRX2 receptor in mast cells (PubMed:12915402, PubMed:34789874, PubMed:34789875). {ECO:0000250|UniProtKB:Q62949, ECO:0000269|PubMed:12915402, ECO:0000269|PubMed:34789874, ECO:0000269|PubMed:34789875}. This is the function of Ensembl gene identifier ENSG00000241563 (CORT, cortistatin).