Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. . This is the function of Ensembl gene identifier ENSG00000249751 (ECSCR, endothelial cell surface expressed chemotaxis and apoptosis regulator).