The function of PYDC2 (pyrin domain containing 2, Ensembl gene identifier ENSG00000253548) is as follows. May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome (PubMed:17178784, PubMed:17339483). May also inhibit NF- kappa-B signaling distally by affecting the nuclear accumulation of RELA (PubMed:17339483, PubMed:24871464). {ECO:0000269|PubMed:17178784, ECO:0000269|PubMed:17339483, ECO:0000269|PubMed:24871464}.