The function of AQP5-AS1 (AQP5 and AQP2 antisense RNA 2, ENSG00000257588) is as follows. Reduces filamentous actin fibers by interacting with aquaporin AQP2 which leads to inhibition of the expression of SEPTIN4 and integrin ITGB4 (PubMed:32176498). Also inhibits the activation of the EREG/EGFR signaling pathway through interaction with AQP2 (PubMed:36117171). {ECO:0000269|PubMed:32176498, ECO:0000269|PubMed:36117171}.