Dual receptor for both endothelin-1 and the signal sequence of vascular endothelial growth factor A (PubMed:17446437, PubMed:24465725). Does not act as a receptor for angiotensin-2 (PubMed:17446437). Does not bind the VEGFA mature protein (By similarity). May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity). {ECO:0000250|UniProtKB:Q2QKR2, ECO:0000269|PubMed:17446437, ECO:0000269|PubMed:24465725}. This is the function of Ensembl gene identifier ENSG00000270751 (FBXW7-AS1, FBXW7 antisense RNA 1).