The function of ENSG00000277481 (PKD1L3, polycystin 1 like 3, transient receptor potential channel interacting) is as follows. Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:19464260, PubMed:23212381). Also shows permeability towards NA(1+), K(+) and Mg(2+) (PubMed:23212381). Heterotetrameric complex channel is activated by external low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:19464260, PubMed:23212381). May act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:19812697). {ECO:0000269|PubMed:19464260, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381}.